Efficient, Robust, and Scalable Bioconjugates Development Platform
· Preparation of PCC for various drug conjugates (ADCs, RDCs, AOCs, etc.)
· Development of conjugation processes with different principals
· Development of customized conjugation and purification process
· Technology transfer and process scale-up
· Process characterization
· Diversified conjugation technology platform:
Proficient in advanced non-site-specific and site-specific conjugation technologies:
·Non-site-specific conjugation technologies such as lysine or cysteine conjugation, etc.
·Site-specific conjugation technologies such as engineered cysteine conjugation technology, interchain cysteine re-bridge conjugaiton technology, sortase enzyme conjugation technology, glycosyl site conjugation technology, etc.
· Familiar with the conjugation characters of different payload-linkers, such as MMAE, DM1, PBD, Dxd, SN-38, etc.
· Efficient delivery: capable of completing process development in 2-3 months on average
· Over 8 years of experience in conjugation and purification development
· Several years of experience in late-stage process characterization
